miércoles, 23 de septiembre de 2015
Seeking help for mental health problems: Change the culture for providers
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What I learned about childproofing from working in the ER
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martes, 22 de septiembre de 2015
The human physician will soon become history. Here’s why.
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Much of the human spirit lies outside a physician’s power
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3 things Walter White can teach doctors
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It is time for an honest conversation about money and cancer
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lunes, 21 de septiembre de 2015
When patient-centered care becomes patient-dictated care
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How good of a clinician are you?
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4 things on the horizon in childhood cancer
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Pain tolerance: A story of two patients
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domingo, 20 de septiembre de 2015
Innovation in health care: Too much, too little, or just right?
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LITFL Review 198
The Most Fair Dinkum Ripper Beauts of the Week
A great new #FOAMcc website is born: ICM Case Summaries! This is what it is all about: “Writing ten expanded case summaries is a requirement of the CCT in Intensive Care Medicine training program for doctors in the UK. These summaries are usually the result of hours of work collecting, synthesising and distilling the most up-to-date evidence on specific clinical questions relevant to intensive care practice in the UK. For most of us though, once they are completed they just sit on our hard drives gathering e-dust. Our aim is to release the untapped potential of these resources and create an online repository of ICM expanded case summaries. As ICM Case Summaries grows it will form a continuously expanding and updating free online educational resource for intensive care medicine professional”. This is an excellent initiative that I hope all UK-based trainees and ICU consultants consider contributing to. The collection of posts is growing rapidly… One to watch! [CN]
The Best of #FOAMed Emergency Medicine
- Excellent review of the evidence behind the use of nitrates and NIPPV in decompensated heart failure in the ED from HEFT EM Cast. Includes the disutility of loop diurectics. [AS]
- More great podcasts coming at a quick-fire rate from CORE EM. This time it’s the management of DKA. [SL]
- The All NYC EM Podcast features Pik Mukherji discussing heuristics and diagnostic errors. [AS]
- Rebecca Maxwell from the Severn FOAMed Network delivers a fantastic podcast on Tricyclic Antidepressant Overdose and discusses the role of intralipid. [SL]
- EM Lit of Note discusses new targets for finding patients amenable to catheter-directed therapy in ischemic CVA for reperfusing at-risk (as opposed to infarcted) tissue. [AS]
- An interesting update on The Alteplase Controversy Goes Prime Time, as the concern over stroke thrombolysis gains more momentum. [SL]
- The Bottom Line reviews an excellent RDCT comparing low dose ketamine to morphine for acute pain management in the ED. [AS]
- Mistakes in medicine are inevitable but rarely gets discussed. This fantastic blog from Sweat the Small Stuff talks about medical errors in a open, honest and informative manner. It is essential reading for all. [SL]
- The latest episode of ERCast delves into the difficulty of deciding “is my patient suicidal”? [MG]
The Best of #FOAMcc Critical Care
- Video demonstration of the core micro-skills necessary for expert central line placement from EM Crit. [AS]
- There has been a surge in case-based Q&As over at INTENSIVE, courtesy of Chris Sia: congenital heart disease in an adult is the focus of Cyanosis, Boots and the 5Ts, key finds on AXR in Belly ache and Rigler’s Sign, and the differential diagnosis of different types of lung opacitites on CXR in Why the alveolar opacities?. [CN]
- Deirdre Murphy (aka ‘ECMO Goddess’!) talks to San Diego’s finest podcasters Joe and Zack about Weaning VA ECMO on the EDECMO.org podcast. The discussion provides great insights into the management and weaning of VA ECMO patients in the ICU. I could have done with hearing this a few years ago! [CN]
- Cardio-pulmonary physiology maven Jon-Emile Kenny has made his Critical Care Medicine board exam review notes available on PulmCCM.org. [CN]
- ScanCrit reviews the recent article in Annals of Surgery looking at the utility of FAST in predicting patients who will not benefit from ED thoracotomy after trauma. [AS]
The Best of #FOAMtox Toxicology
- ECMO makes a double mention this week at the Poison Review: ECMO as a bridge to lung transplantation in paraquat poisoning and ECMO in colchicine poisoning [JAR]
- How does obesity affect the poisoned patient? The Poison Review discusses a recent article on the topic. [AS]
The Best of #FOAMped Paediatrics
- New free iBook – Pediatric Emergency Medicine Guidelines. [AS]
The Best of Medical Education and Social Media
- Excellent podcast discussing how we can reconcile novel education (i.e. FOAM) with the traditional models at Injectable Orange featuring Vic Brazil and Damian Roland. [AS]
- If you’ve got a presentation to give soon then this is a must listen! Jonathan Downham talks to Ross Fisher on how to make a fantastic presentation. [SL]
News from the Fast Lane
- There are now over 1,600 entries in the Critical Care Compendium… and counting! [CN]
Reference Sources and Reading List
- Emergency Medicine and Critical Care blog/podcast list
- LITFL Global Blogroll
- FOAMEM RSS feed syndication for global FOAM
- Twitter: #FOAMed – #FOAMcc – #FOAMtox – #FOAMped – #FOAMus – #FOAMim
Brought to you by:
- Anand Swaminathan [AS] (EM Lyceum, iTeachEM)
- Brent Thoma [BT] (BoringEM and Academic Life in EM)
- Chris Connolly [CC]
- Chris Nickson [CN] ( iTeachEM, RAGE, INTENSIVE and SMACC)
- Joe-Anthony Rotella [JAR]
- Kane Guthrie [KG]
- Mat Goebel [MG]
- Segun Olusanya [SO] (JICSCast)
- Simon Laing [SL] (HEFTEMCast)
- Tessa Davis [TRD] (Don’t Forget The Bubbles)
- Marjorie Lazoff [ML]
The post LITFL Review 198 appeared first on LITFL: Life in the Fast Lane Medical Blog.
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Why doctors and digital experts should work together to improve patient health
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I despise my EHR. But I’m still using it.
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The story of the pot-smoking neurosurgeon is more complicated than you think
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sábado, 19 de septiembre de 2015
Doctors should beware the attribution sign. Here’s why.
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How a head CT changed everything for this patient
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Are physicians really to blame for the opioid addiction epidemic?
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Test your medicine knowledge: 33-year-old woman with atrial fibrillation
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viernes, 18 de septiembre de 2015
The human cost of breast cancer screening
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Why it’s important for physicians to talk about bias
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Who is caring for the caregivers? A medical scribe’s perspective.
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Sometimes the best care a patient can get is a discussion
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jueves, 17 de septiembre de 2015
Funtabulously Frivolous Friday Five 117
Question 1
+ Reveal the Funtabulous Answer
- Thigh hyperpigmentation
- This sign was described in 1963.
- Hyperpigmentation on the thighs is caused by repeated pressure from sitting in a tripod position (similar to Rodin’s Thinker).
- Most patients suffer from COPD [Reference]
Question 2
+ Reveal the Funtabulous Answer
- Asthma
- Spiralled mucous plugs containing shed epithelium
- Most often seen in the sputum of asthmatics (but can also be in several lung diseases). [Reference]
Question 3
+ Reveal the Funtabulous Answer
- Infection with Burholderia pseudomallei
- Vietnam war veterans often developed this, up to a decade after returning from Vietnam.
- It is hypothesised the helicopter blades would spin the bacteria into the air as the soldiers were embarking or disembarking.
- B.pseudomallei is a slow growing bacteria and presenting with a broad spectrum of symptoms from dermal rashes to liver abscess. Mortality can be as high as 40%. [Reference]
Question 4
+ Reveal the Funtabulous Answer
- Uhthoff’s phenomenon
- This episode may be an exacerbation of multiple sclerosis
- MS symptoms exacerbated by heat and exercise (e.g. exercise increasing body temp) is known as Uhthoff’s phenomenon. [Reference]
Question 5
+ Reveal the Funtabulous Answer
- The term is derived from the Latin word palliare – which means “to cloak“.
- The first hospices (in the current/”medical” sense) were established in 1967, although hospice-like facilities have existed since the fourteenth century. [Reference]
…and in other news
The post Funtabulously Frivolous Friday Five 117 appeared first on LITFL: Life in the Fast Lane Medical Blog.
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Caring for the dying patient is a rewarding challenge
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The first step to combat the nation’s obesity epidemic
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A letter from an educator to medical trainees
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The time to reinvent medicine is now. #TakeBackMedicine
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miércoles, 16 de septiembre de 2015
TechTool Talk 005 with James Edwards
As part of TechTool Thursday, I thought it would be interesting to look at more than just app reviews. This week I interview James Edwards
Tell me a bit about your medical background/career?
What led to you starting onthewards?
Where did you learn your IT skills?
What is the aim of onthewards?
Didn’t you find trying to get onthewards up and running within the hospital system to be a bureaucratic nightmare?
What has been the key to your success developing onthewards so far?
What are your aims for onthewards for the next couple of years?
Updating the website and developing an onthewards app for mobile devices.
Continuing to collaborate more widely outside our hospital.
Encouraging more FOAM websites aimed at junior doctors.
Is onthewards FOAM and are you aiming to keep it that way?
What or who inspires you?
What is the best piece of advice you have been given?
The post TechTool Talk 005 with James Edwards appeared first on LITFL: Life in the Fast Lane Medical Blog.
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Research and Reviews in the Fastlane 100
This edition contains 6 recommended reads. The R&R Editorial Team includes Jeremy Fried, Nudrat Rashid, Soren Rudolph, Anand Swaminathan and, of course, Chris Nickson. Find more R&R in the Fastlane reviews in the R&R Archive, read more about the R&R project or check out the full list of R&R contributors
This Edition’s R&R Hall of Famer
Palliative Care, Critical Care
Kelley AS, Morrison RS. Palliative Care for the Seriously Ill. NEJM 2015; 373:747-755. PMID: 26287850
- This excellent review article emphasizes palliative care being interdisciplinary care involving multiple specialities e.g. medicine, nursing, social work, chaplaincy, etc which focuses on improving quality of life for persons of any age who are living with any serious illness and for their families. Core components of palliative care include the assessment and treatment of physical and psychological symptoms, identification of and support for spiritual distress, expert communication to establish goals of care and assist with complex medical decision making, and coordination of care. Excellent cognitive road maps for Breaking Bad News such as SPIKES (setting up the interview, assessing the patient’s perception, obtaining the patient’s invitation, giving knowledge and information, responding to emotion, and summarizing the discussion), and others to express empathy with the use of NURSE (naming, understanding, respecting, supporting, and exploring) are described and could be utilised in our practise.
- Recommended by: Nudrat Rashid
The Best of the Rest
Gaeta F et al. Tolerability of aztreonam and carbapenems in patients with IgE-mediated hypersensitivity to penicillins. J Allergy Clin Immunol. 2015;135(4):972-6. PMID: 25457154
- True penicillin allergy can potentially limit antibiotic options as many antibiotics from cephalosporins to carbapenems to aztreonam have reported cross-reactivity. A number of publications have shown low cross-reactivity (1-3%) between penicillins and cephalosporins as well as low cross-reactivity between penicillins and imipenem/meropenem (~ 1%). This study, using skin tests, found that 0 out of 211 patients demonstrated cross-reactivity between penicillin and aztreonam. The authors recommend skin testing prior to administration and skin testing isn’t a perfect surrogate for a systemic reaction upon IV administration but the best evidence we have shows that cross-reactivity is highly unlikely.
- Recommended by: Anand Swaminathan
Pediatrics
Park G et al. Randomized single-blinded clinical trial on effects of nursery songs for infants and young children’s anxiety before and during head computed tomography. Am J Emerg Med. 2015. PMID: 26314215
- This RCT randomized children aged <4 years who were undergoing CT scans to receive either nursery rhymes (via musical CD) or standard care (with no music). The children who received the music had significantly lower agitation scores measured using a visual analogue scale (absolute difference 2.4 cm, p=0.03). The paper has some weaknesses. For example, even though the research associate assessing agitation wore earphones to block out any music, they seem unlikely to have been truly blinded to allocation because they’ll have seen the child’s reaction. What’s more, the difference is modest. Still, it’s a nice idea and gives us some evidence (even if it does have weaknesses) to suggest that music might be helpful in this situation.
- Recommended by: Rick Body
Emergency Medicine
Un, et al. Novel Vagal Maneuver Technique for Termination of Supraventricular Tachycardias. AJEM 2015 PMID: 26209466
- A brief case series that describes the success of a new vagal maneuver for termination of SVT in the emergency setting. Basically, the authors describe moving patients quickly from a sitting to a supine position, and their success with 5 different patients. This is certainly a benign enough procedure without significant foreseeable harm, so well worth attempting before placing an IV and pushing adenosine. Another arrow in the quiver!
- Recommended by: Jeremy Fried
Critical care
Kosova E, Bergmark B, Piazza G. Fat embolism syndrome. Circulation 2015;131(3):317-20. PMID: 25601951
- Although a review, this article highlights a rare, but important and often misdiagnose entity: Fat Embolism Syndrome (FES). FES is defined as the presence of fat globules in pulmonary circulation. Common affected population are young (10-40) patients with long bong trauma but it can be seen in pathological fractures or bone marrow disease. The pathophysiology is thought to be related to a mechanical obstruction plus a sever inflammatory process (similar to amniotic fluid emboli). Classic presentation is respiratory failure, neurological abnormalities and petechiae. Diagnosis is challenging and based on clinical presentation, isolation of fat particles in wedge circulation appears not to be of great help for the diagnosis, the authors recommend the use of Gurd criteria (http://bit.ly/1umarLp). Treatment consists in general aggressive intensive care support.
- Recommended by: Daniel Cabrera
Systems and Administration
Asch DA, Rosin R. Innovation as Discipline, Not Fad. NEJM 2015; 373(7):592-594. PMID: 26267619
- Most of us have a bunch of ideas that we think might make our hospital work better.Most of us do not implement those ideas.This is because full implementation would take a bunch of money or resources to build a whole system. So we are stuck unable to implement a fix because we cannot get the resources; unable to get the resources because we do not have evidence it will work; and unable to get the evidence it will work because we cannot implement the fix.Asch and Rosin provide a set of ingenious solutions for breaking out of this bind. They describe a set of strategies stolen from the technology industry but that they are implementing in healthcare. (Rosin used to work for Quicken, of tax accounting fame.)Pertinently, they provide pragmatic strategies for being able to develop a test-able fix without making most of the investment needed to make a permanent fix. If the test-able fix works, one has evidence to command the resources to make in permanent. If it does not, no harm done, one can move on quickly to a new test-able fix.Particularly for people early in their careers—or in resource-poor environments—these strategies seem enormously useful. The article prompted a bunch of ideas for me, anyway. The bottom line: don’t wait until everything can be done perfectly; find the critical part of a potential solution, find a way that might be good enough to make it better, objectively evaluate it in a real situation, and learn from the result.
- Recommended by: Jack Iwashyna
The R&R iconoclastic sneak peek icon key
The list of contributors | The R&R ARCHIVE | ||
R&R Hall of famer You simply MUST READ this! | R&R Hot stuff! Everyone’s going to be talking about this | ||
R&R Landmark paper A paper that made a difference | R&R Game Changer? Might change your clinical practice | ||
R&R Eureka! Revolutionary idea or concept | R&R Mona Lisa Brilliant writing or explanation | ||
R&R Boffintastic High quality research | R&R Trash Must read, because it is so wrong! | ||
R&R WTF! Weird, transcendent or funtabulous! |
That’s it for this week…
That should keep you busy for a week at least! Thanks to our wonderful group of editors and contributors Leave a comment below if you have any queries, suggestions, or comments about this week’s R&R in the FASTLANE or if you want to tell us what you think is worth reading.
The post Research and Reviews in the Fastlane 100 appeared first on LITFL: Life in the Fast Lane Medical Blog.
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The top 10 mistakes premedical students make
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Can you teach the art of medicine?
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The problems with patient feedback forms and how to fix them
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#NursesUnite against The View. It’s time to set the record straight.
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Patients are taking far too many medications. It’s time to fix that.
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martes, 15 de septiembre de 2015
After a drug overdose: Is it malpractice or murder?
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The tragedy of opioid addiction in the young and homeless
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You can’t tell whether a psychotherapist is impaired
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Why we are #ProudtobeGIM: A general internal medicine top 10 list
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What to say when medical certainty is elusive
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lunes, 14 de septiembre de 2015
Medicine can still be noble. If we fight for it.
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Treating cancer: Doing nothing is also a choice
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The cafeteria can tell you a lot about the hospital. Here’s how.
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Less regulation in health care. Please.
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domingo, 13 de septiembre de 2015
Can you fake empathy until it becomes real?
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LITFL Review 197
The Most Fair Dinkum Ripper Beauts of the Week
Want to hear a specific article critically appraised? Submit your picks to The SGEM using their superb Hot or Not process, a fantastic new FOAMed feature. [SL]
A superb new resource collating intensive care case series, with evidenced-based answers to really useful clinical questions: icmcasesummaries.com. [SL]
The Best of #FOAMed Emergency Medicine
- Dr. Smith’s ECG Blog discusses the short differential diagnosis list for a large R wave in V1. [AS]
The Best of #FOAMcc Critical Care
- Anton Helman welcomes Rich Levitan, Andy Sloas and David Barbic to discuss the management of the critically ill obese patient. [AS]
- Chris Hicks discusses the 10 Commandments of Trauma Resusc on REBEL EM. [AS]
The Best of #FOAMus Ultrasound
- The US of the Week blog highlights a case of necrotizing fasciitis rapidly identified by POCUS. [AS]
The Best of #FOAMtox Toxicology
- Core EM reviews hyperinsulinemia-euglycemia therapy in the treatment of calcium channel blocker overdose. [AS]
- If you missed last week’s News from the Fast Lane: the LITFL team has developed the Toxicology Library! Check it all out here. [ML]
The Best of #FOAMped Paediatrics
- Don’t Forget the Bubbles has teamed up with APLS to release the videos from the 2013 and 2014 Paediatric Acute Care Conference, online and freely available; after this year’s conference in October, the videos from 2015 are promised to appear online as well. Their first video is Gary Williams on Emerging Viral Infections. [TRD]
The Best of #FOAMim Internal Medicine
- As the folks at Louisville Lectures are still on summer break, you have time to catch up on the specialty list of Grand Rounds-type lectures online posted over the past year. [ML]
The Best of Medical Education and Social Media
- The Skeptics Guide to EM (SGEM) goes global with new podcasts in French, Spanish and Portugese. [AS]
News from the Fast Lane
- There are now over 1,600 entries in the Critical Care Compendium… and counting! [CN]
Reference Sources and Reading List
- Emergency Medicine and Critical Care blog/podcast list
- LITFL Global Blogroll
- FOAMEM RSS feed syndication for global FOAM
- Twitter: #FOAMed – #FOAMcc – #FOAMtox – #FOAMped – #FOAMus – #FOAMim
Brought to you by:
- Anand Swaminathan [AS] (EM Lyceum, iTeachEM)
- Brent Thoma [BT] (BoringEM and Academic Life in EM)
- Chris Connolly [CC]
- Chris Nickson [CN] ( iTeachEM, RAGE, INTENSIVE and SMACC)
- Joe-Anthony Rotella [JAR]
- Kane Guthrie [KG]
- Mat Goebel [MG]
- Segun Olusanya [SO] (JICSCast)
- Simon Laing [SL] (HEFTEMCast)
- Tessa Davis [TRD] (Don’t Forget The Bubbles)
- Marjorie Lazoff [ML]
The post LITFL Review 197 appeared first on LITFL: Life in the Fast Lane Medical Blog.
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All actors should have to take a CPR class
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How anatomy lab changed this medical student forever
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The day I saw the humanity in medicine
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sábado, 12 de septiembre de 2015
Now is the time for acute pain medicine specialists
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3 ways to improve your delivery of bad news to patients
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Let’s remove the uncertainty hospitalized patients endure
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Test your medicine knowledge: 22-year-old man with diarrhea and weight loss
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viernes, 11 de septiembre de 2015
Medicine can suck the compassion out of you. But I still give it my best shot.
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Academic medicine still discriminates against women. Here’s one story.
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I wish HIPAA had privacy settings
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6 reasons why doctors grieve differently
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jueves, 10 de septiembre de 2015
Funtabulously Frivolous Friday Five 116
Question 1
+ Reveal the Funtabulous Answer
- Iodine deficiency
- Thyroid goitre due to iodine deficiency. [Reference]
- In the 18th Century, doctors were baffled by a mysterious condition that affected many of the people of Derbyshire. The afflicted, were mostly women and suffered a swelling on the bottom of their throats.
- “It generally occupies the whole front of the neck,” said local scholar Thomas Prosser, “as the whole thyroid gland is here generally enlarged, but is rather in a pendulous form, not unlike the flap or dew-cap of a turkey cock’s neck.”
Question 2
+ Reveal the Funtabulous Answer
- Professor Touery
- In front of his distinguished colleagues at the French Academy of Medicine, Professor Touery ingested 15g of strychnine (a lethal dose) mixed with activated charcoal – and lived to tell the tale. [Reference]
- M. Bertrand (a French chemist) was the first to perform such a daring experiment on himself to demonstrate the effectiveness of charcoal to absorb poison. In 1813 he ingested a lethal dose of arsenic after mixing it with activated charcoal. He survived his experiment.
Question 3
+ Reveal the Funtabulous Answer
- …solving the Arab-Israeli conflict in the middle East
- At least according to Edward de Bono in advice he tendered to the foreign office in 2000.
- The logic, briefly, is this. Hypozincemia makes men irritable and belligerent. You get zinc in yeast, which is fine for your average loaf of bread. But in the Middle East, the bread is unleavened. Ergo, the great man says, Marmite is the answer to easing the way to peace. [Reference]
Question 4
+ Reveal the Funtabulous Answer
- They need big shoes
- According to a study in 2002 published in the British Journal of Urology International there is no link between the size of a mans penis and is shoe size.
- 104 subjects were thoroughly measured at two hospital sites in the UK and they found the average Caucasian penis to be 3.5 inches (8.9cm) long with no correlation to shoe size. [PMID 12230622]
- Additional information can be found…for the uber inquisitive in a study of nomogram charting penile length studies in 15,000 men [“Am I normal…” PMID 25487360]
Question 5
+ Reveal the Funtabulous Answer
- Demonstration of interference in the reaction time of a task
- Classically, naming the colour of the first set of words is easier and quicker than the second. The original paper is one of the most quoted in experimental physiology. It has been used in dementia, brain injury, ADHD patients and even on Everest to test attention capacity. [Reference]
…and in other news
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A little girl stopped this physician from asking why
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TechTool Thursday 064 Touch Surgery
TechTool review Touch Surgery on iOS and Android
The Touch Surgery app is unlike any app I’ve seen before. It simulates surgical procedures to allow teaching and testing of students and trainees. Touch Surgery has a huge team behind it who have created surgical simulation software. The procedures and operations contained in the app are authored by different surgeons from across the world.The aim is to develop a collaborative resource consisting of best surgical practice in order to share and learns with other health professionals
Website: – iTunes – Android – Website
Design
This app is a pleasure to use. Everything from the icon, the screen layout, the fonts, and colour schemes are just right. Navigation through the app is smooth and it did not crash on me at all. A model for how medical apps should look
User Interface
Clinical Content
- The app contains over 50 surgical procedures.
- A couple are included when you install the app, others have to be downloaded.
- The modules cover a range of surgical specialties and include procedures from chest tube insertion to acute trauma craniotomy
- When you enter your area of interest, the app suggests videos that might interest you.
- Each module has ‘test’ and ‘learn’ options. The learn option shows you step-by-step how to complete a surgical procedures. After this, you can test your knowledge.
- All the modules use excellent graphics and gestures to allow the user to interactively learn.
Cost
- The app is completely free.
- I’m astounded that it is, as it would be reasonable to charge users $10 to purchase this. I assume that Touch Surgery makes money by licensing it out to institutions to use for teaching and for the development of new operations
Room for Improvement
- When setting up my free account I was only asked to enter my password once, and couldn’t see the password to check I had typed it correctly. This has the potential to result in frustrated users who are locked out of their accounts due to password typos.
- All of the modules took a long time to download – potentially this was due to my internet connection but I downloaded via a fast wifi connection.
- I struggled to find out how to open and start new modules – when it looked like they were finally downloaded, the button to start them was missing. Was my account restricted in some way? If so, the app should make this clear.
- Another module that appeared to be downloaded told me there was an error with module when I tried to start it.
Overall
I seemed to have a lot of bad luck when using this app, however. I suspect some of the restrictions were due to pending verification of my account, but if this was made clearer in the app then it would be less frustrating for users.
The modules that I was able to complete were really helpful from an anatomy point of view, and also will be handy if I ever decide on a career change. I now feel pretty confident that I could do a carpal tunnel release without any supervision, so maybe I’ll look at surgical training next.
//www.youtube.com/watch?v=UiWHXO5fAbA
The post TechTool Thursday 064 Touch Surgery appeared first on LITFL: Life in the Fast Lane Medical Blog.
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I started singing in the procedure room. And it reshaped my view of professionalism.
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Is your hospital a miserable place to work? Here are 14 clues.
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Informed consent defines 21st-century medicine
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miércoles, 9 de septiembre de 2015
Discussing the side effects of medications: How can doctors do better?
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Research and Reviews in the Fastlane 099
This edition contains 5 recommended reads. The R&R Editorial Team includes Jeremy Fried, Nudrat Rashid, Soren Rudolph, Anand Swaminathan and, of course, Chris Nickson. Find more R&R in the Fastlane reviews in the R&R Archive, read more about the R&R project or check out the full list of R&R contributors
This Edition’s R&R Hall of Famer
Peri-operative Medicine, Cardiology
Douketis JD et al. Perioperative bridging anticoagulation in patients with atrial fibrillation. N Engl J Med. 2015; 373(9):823-833. PMID: 26095867
- This randomized, double-blind, placebo-controlled trial assigned patients with chronic (permanent or paroxysmal) atrial fibrillation or flutter who had received warfarin therapy for 3 months or longer, with an international normalized ratio (INR) therapeutic range of 2.0 to 3.0 and were undergoing an elective operation or other elective invasive procedure that required interruption of warfarin therapy; and had at least one of the CHADS2 stroke risk factors to receiving bridging anticoagulation therapy with dalteparin sodium (100 IU per kilogram of body weight administered subcutaneously twice daily) or to receive no bridging therapy (i.e., a matching subcutaneous placebo) from 3 days before the procedure until 24 hours before the procedure and then for 5 to 10 days after the procedure. The results showed that for this group of patients a strategy of forgoing bridging anticoagulation was noninferior to perioperative bridging with low-molecular-weight heparin for the prevention of arterial thromboembolism. The strategy of forgoing bridging treatment also decreased the risk of major bleeding.
- Recommended by: Nudrat Rashid
The Best of the Rest
Emergency Medicine
Macy E, Contreras R. Health care use and serious infection prevalence associated with penicillin ‘‘allergy’’ in hospitalized patients: A cohort study. J Allergy Clin Immunol. 2014;133(3):790-6. PMID: 24188976
- Allergy to penicillin class drugs is extremely common. However, most studies show that only 1-5% of patients who claim an allergy actually have one. This article investigates the additional costs that occur as a result of penicillin ʺallergyʺ being placed on a chart. In this observational study, the authors found that patients had longer hospitalizations and at more risk for C.diff, MRSA and VRE infections. Overall, they found that it would be much cheaper and more efficient to test every patient to try and establish true allergy (or more likely, absence of allergy) than to continue to spend health care dollars in this way.
- Recommended by: Anand Swaminathan
Emergency Medicine
Murphy N et al. Gestation-specific D-dimer reference ranges: a cross-sectional study. Br J Obstet Gyn 2015; 122:(3)395-400. PMID: 24828148
- The workup of pregnant patients with possible pulmonary embolism is complicated because the beloved decision aids haven’t been validated for use in this population and we know d-dimer levels increase naturally during gestation. This study took a sample from healthy pregnant patients (n=760) at different stages of gestation. They found, unsurprisingly, that d-dimer increases with gestational age, congruent with limited prior literature. They propose a continuous increasing d-dimer in pregnancy. With PE experts such as Dr. Kline proposing gestation adjusted d-dimer, this is a research space to watch.
- Recommended by: Lauren Westafer
Systems and administration
Del Portal DA, et al. Impact of an Opioid Prescribing Guideline in the Acute Care Setting. J Emerg Med 2015. PMID: 26281819
- As many EDs implement voluntary opioid prescribing guidelines, this study is the first of it’s kind to examine outcomes after doing so. The prescription opioid abuse epidemic in the U.S. is a well known problem and a black eye on the face of medicine as it’s an issue we created in an attempt to alleviate the suffering of our patients. Unfortunately, the pendulum clearly swung too far to the side of liberal distribution and we are now dealing with the consequences of over prescribing. The authors in this study detail their experience implementing a voluntary guideline at multiple ED sites. They found that opioid prescriptions for dental, neck, back, or unspecified chronic pain decreased from 52.7% before the guideline to 29.8% immediately after its introduction, and to 33.8% at an interval of 12 to 18 months later. Additionally, 100% of ED faculty supported the guideline. Importantly, providers were able to ʺoverrideʺ the guideline at their discretion and a state prescription monitoring database was not available at the time of the study.
- Recommended by: Jeremy Fried
Ultrasound and imaging
Bouhemad B et al Ultrasound for ʺlung monitoringʺ of ventilated patients. Anesthesiology 2015; 122(2):437-47. PMID 25501898
- The use of lung ultrasound (LUS) is ever expanding. Today we know several specific LUS patterns corresponding to lung pathology and for some of these we have couple specific treatments. However the problem with LUS has mostly been how to communicate findings between clinicians and to monitor these over time. This paper offers a scoring system to monitor degree of lung aeration over time and as response to specific treatments, ie PEEP and prone position, in the ventilated patient.
- Recommended by: Søren Rudolph
The R&R iconoclastic sneak peek icon key
The list of contributors | The R&R ARCHIVE | ||
R&R Hall of famer You simply MUST READ this! | R&R Hot stuff! Everyone’s going to be talking about this | ||
R&R Landmark paper A paper that made a difference | R&R Game Changer? Might change your clinical practice | ||
R&R Eureka! Revolutionary idea or concept | R&R Mona Lisa Brilliant writing or explanation | ||
R&R Boffintastic High quality research | R&R Trash Must read, because it is so wrong! | ||
R&R WTF! Weird, transcendent or funtabulous! |
That’s it for this week…
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